Search - Number 3 - THE DYNAMICS OF TRANSMEMBRANE REDOX EQUIVALENTS FLUX AS A BIODOSIMETRIC CHARACTERISTIC OF AN IRRADIATED BODY

THE DYNAMICS OF TRANSMEMBRANE REDOX EQUIVALENTS FLUX AS A BIODOSIMETRIC CHARACTERISTIC OF AN IRRADIATED BODY
Cover not present THE DYNAMICS OF TRANSMEMBRANE REDOX EQUIVALENTS FLUX  AS A BIODOSIMETRIC CHARACTERISTIC OF AN IRRADIATED BODY
Category: Number 3
Publication: 3
Summary

Varies stressor influences upon the cell induce compensatory reactions, firstly those of glutathione-dependent enzymes. Since, the increasing reduced nicotinamide adenine dinucleotide phosphate consumption occurs that is been synthesizing by means of hexose monophosphate glucose metabolism pathway. The lack of its resources for antioxidant homeostasis keeping is followed by those enzymes depression and oxidative stress development. The assay of healthy donors' blood samples after extracorporal 25 cGy or 50 cGy gamma-irradiation, as well as the blood samples of gamma teletherapy-treated tumor patients have demonstrated distinctive changes of transmembrane redox equivalents flux in their erythrocytes. The dynamic performance of these changes reflects the stress rate and functional capabilities of antioxidant defense system. The approach presented could be used for consequences of low-dose radiation influence prediction.