Search - Number 3 - COMPARATIVE ANALYSIS OF CYTOGENETIC MANIFESTATIONS OF HUMAN GENOME INSTABILITY

COMPARATIVE ANALYSIS OF CYTOGENETIC MANIFESTATIONS OF HUMAN GENOME INSTABILITY
Cover not present COMPARATIVE ANALYSIS OF CYTOGENETIC MANIFESTATIONS OF HUMAN GENOME INSTABILITY
Category: Number 3
Publication: 3
Summary

The comparative analysis of cytogenetic manifestations of human genome instability was carried out. The studied parameters are the micronuclei rate (MNR), the level of single and double chromosome fragment and tle level of premature chromatid division (PCD). PCD and chromosome fragments were chosen as anomalies that possibly result in MN formation. We analysed the MNR in buccal epithelium (BE) and peripheral blood lymphocytes (PBL), the level of single and double chromosome fragment as well as level PCD - in PBL only. Average MNR in BE was higher than in PBL and they 4,01 0,23 ‰ and 2,58 0,23 ‰ respectively. Average level of single and double chromosome fragment was 1,73 0,23 %, PCD - 1,68 0,33 %. The correlation analysis did not revealed statistically significant correlation of selected parameters. Thus, the studied parameters are independent ones and have to be considered altogether for more comprehensive evaluation of the level and peculiarities of manifestation of human genome instability.