Search - Number 3 - THE OXIDATIVE MECHANISM EFFECT OF LOW-LEVEL IONIZING RADIATION ON THE HIGHER NERVOUS ACTIVITY RATS INVESTIGATION

THE OXIDATIVE MECHANISM EFFECT OF LOW-LEVEL IONIZING RADIATION ON THE HIGHER NERVOUS ACTIVITY RATS INVESTIGATION
Cover not present THE OXIDATIVE MECHANISM EFFECT OF LOW-LEVEL IONIZING RADIATION   ON THE HIGHER NERVOUS ACTIVITY RATS INVESTIGATION
Category: Number 3
Publication: 3
Summary

The aim of this study was to investigate the oxidative stress mechanism of the higher nervous activity of the animals disturbances caused by the exposure to ionizing radiation (0,05 Gy). Methods of studies: behavioral (shuttle-box), statistical. The effect of the ionizing radiation upon the indices of behavioral reaction of rats as well as ability some antioxidants (alpha-tocopherol, ascorbic acid, beta-carotene) used separately and in complexes to diminish exposure effects according to the studies indices have been studied. The largest protective effect was found for beta-carotene as well for the compositions, witch contain it. In the case of the animal exposure at the dose of 0,05 Gy, usage of alpha-tocopherol could case decline of the rats behavior reactions indices; this suggest that usage of antioxidant therapy demands certain cautiousness. The indices of the animals behavior reactions could be used for the assessment of the antioxidant preparations effectiveness under the exposure to the agents the effect of which is mediated by the oxidant stress mechanism. The obtained results suggest the contribution of the oxidant stress component to be leading at least in dose of 0,05 Gy.